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I4011
Sigma
Insulin from bovine pancreas
Hybri-Max™, powder, hybridoma tested
| CAS Number: | 11070-73-8 |
| Linear Formula: | C254H377N65O75S6 |
| Molecular Weight: | 5733.49 |
| EC Number: | 234-291-2 |
| MDL number: | MFCD00131380 |
Description
| Biochem/physiol Actions | Two-chain polypeptide hormone produced by the β-cells of pancreatic islets. Its molecular weight is ~5800 Da. The α and β chains are joined by two interchain disulfide bonds. The α chain contains an intrachain disulfide bond. Insulin regulates the cellular uptake, utilization, and storage of glucose, amino acids, and fatty acids and inhibits the breakdown of glycogen, protein, and fat. |
| Legal Information | Hybri-Max is a trademark of Sigma-Aldrich Biotechnology LP and Sigma-Aldrich Co. |
Properties
| grade | Hybri-Max™ |
| form | powder |
| potency | ≥27 USP units per mg |
| total impurities | Endotoxin, tested |
| solubility | acidified water, pH 2.0: 2 mg/mL |
| cation traces | Zn: ~0.5% |
| suitability | hybridoma tested |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
References
| reference | Smith, L.F., Species variation in the amino acid sequence of insulin. Am. J. Med. 40, 662-666, (1966) |
| Kono, T., Insulin-sensitive glucose transport. Vitam. Horm. 7, 103-154, (1988) | |
| Merck | Merck 13,5003 |
